Animal-Free Recombinant Human IFN-γ
 
Catalog Number:

AF-300-02

Synonyms:

Immune Interferon, type II interferon, T cell interferon, MAF

重組人干擾素γ詳細(xì)描述如下：

         IFN-γ是由CD4和CD8 T淋巴細(xì)胞以及活化NK細(xì)胞產(chǎn)生的酸不穩(wěn)定干擾素。IFN-γ受體存在于大多數(shù)免疫細(xì)胞，其響應(yīng)通過增加I類MHC蛋白的表面表達(dá)，以IFN-γ信號傳導(dǎo)。這促進(jìn)了抗原與T-輔助（CD4+）細(xì)胞的呈現(xiàn)。的IFN-γ的抗原呈遞細(xì)胞信令和識別抗原的B和T淋巴細(xì)胞，調(diào)節(jié)免疫應(yīng)答的抗原特異性相。此外，IFN-γ刺激了許多淋巴樣細(xì)胞的功能，包括巨噬細(xì)胞，NK細(xì)胞和嗜中性粒細(xì)胞的抗微生物和抗腫瘤應(yīng)答。人IFN-γ是物種特異性的，具有生物活性僅在人類和靈長類動物細(xì)胞。重組人IFN-γ的是含有144個氨基酸殘基16.8 kDa的蛋白質(zhì)。Manufactured using all Animal-Free reagents.

Animal-Free Recombinant Human IFN-γ Description:

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells.  IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins.  This promotes the presentation of antigen to T-helper (CD4+) cells.  IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response.  Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils.  Human IFN-γ is species-specific and is biologically active only in human and primate cells.  Recombinant Human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues. Manufactured using all Animal-Free reagents.

AA Sequence:

MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Animal-Free Recombinant Human IFN-γ訂購信息如下：

Animal Free Recombinant Protein    AF-300-02    AF-300-02-100    Human IFN-gamma    100ug    Standard
Animal Free Recombinant Protein    AF-300-02    AF-300-02-250    Human IFN-gamma    250ug    Bulk
Animal Free Recombinant Protein    AF-300-02    AF-300-02-500    Human IFN-gamma    500ug    Bulk
Animal Free Recombinant Protein    AF-300-02    AF-300-02-1000    Human IFN-gamma    1000ug    Bulk

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